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The effect of berberine supplementation on obesity indices: A dose- response meta-analysis and systematic review of randomized controlled trials.

Department of Cardiovasology, The Second People's Hospital of Liaocheng, Linqing, Shandong Province, 252600, China. Department of Cadre Health Care, Qingdao Municipal Hospital, Qingdao, Shandong Province, 266011, China. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Student Research Committee, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Centre for Sport, Exercise, and Life Sciences, Coventry University, Coventry, CV15FB, UK. Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474, Bucharest, Romania. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Department of Community Nutrition, Students' Scientific Research Center (SSRC), School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Department of Clinical Nutrition, Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Cardiology, Qingdao Hiser Medical Center, No.4, People's Road, Sifang District, Qingdao, Shandong Province, 266033, China. Electronic address: zhangjt2019@sina.com.

Complementary therapies in clinical practice. 2020;:101113
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Abstract

BACKGROUND and purpose: Clinical studies investigating the effects of berberine supplementation on anthropometric indices in humans have generated inconsistent results. Thus, the objective of this systematic review and meta-analysis was to clarify the effects of berberine supplementation on obesity indices in human subjects. METHODS Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger's test. RESULTS Overall, 10 studies were included. The combined outcomes suggested a significant influence of berberine administration on body mass index (BMI) (WMD: -0.29 kg/m2, 95% CI: -0.51 to -0.08, p = 0.006) and waist circumference (WC) (WMD: -2.75 cm, 95% CI: -4.88 to -0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: -0.11 kg, 95% CI: -0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = -0.02) and WC (r = -0.72) based on treatment duration. CONCLUSION The results of the current study support the use of berberine supplementation for the improvement of obesity indices.

Methodological quality

Publication Type : Meta-Analysis

Metadata

MeSH terms : Body Weight ; Obesity